Neurodegenerative diseases are characterised by the disruption of normal physiological processes in the brain which support healthy cognitive function and clearance of pathological proteins.
In a healthy brain, normal neuronal function is maintained by key physiological support mechanisms. These include homeostatic glial cell function and the restorative process of sleep. These pathways provide support for neuronal activity and help clear toxic proteins and metabolic waste from the brain.
In a brain ravaged by neurodegenerative disease such as Alzheimer’s disease, these processes are disrupted by the build up of toxic proteins. Impaired physiological support leads to disruption of the normal function of neurons. This neuronal disruption drives disease symptoms such as cognitive decline, and prevents the natural mechanisms which clear toxins.
AstronauTx is developing a portfolio of small molecule therapeutics which will restore and enhance the healthy physiology of the brain by boosting the natural physiological mechanisms which support healthy brain function.
This novel and orthogonal approach to treating neurodegenerative disease will both improve the symptoms of the disease and prevent the vicious cycle of worsening pathology.
“AstronauTx is at the forefront of a novel approach to treating neurodegenerative diseases by restoring dysregulated physiology to both improve symptoms and slow or halt disease progression.”
