Pathological proteins such as β-amyloid, tau and α-synuclein accumulate in neurodegenerative diseases.
As these proteins build up they disrupt normal neurophysiology causing the symptoms of neurodegenerative diseases such as Alzheimer’s and Parkinson’s
The brain normally clears this toxic material and consolidates memories at night, enabling normal neuronal function by day. These protective processes are overwhelmed as neurodegeneration progresses. The resulting toxin build up and disrupted metabolic, synaptic and network function drives the increasing cognitive deficit in patients.
Disruption of normal clearance mechanisms, metabolism, and synaptic networks causes a vicious cycle of worsening symptoms and increasing pathology.
The mechanisms we are targeting will have multifactorial benefits by improving the clearance of toxic species from the brain, improving memory consolidation, boosting metabolism for efficient network function and secreting trophic support for long-term neuronal health.
Enhancing protective clearance mechanisms and memory consolidation at night will prevent further toxin deposition and spread of toxic misfolded proteins that drive neurodegenerative diseases.
Enhancing neural support through energy and growth factor provision by day will maintain metabolic, synaptic and network health and improve neurophysiological function.